Human parechovirus (HPeV) is increasingly being recognized as a potentially severe viral infection in neonates and young infants. HPeV belongs to the family Picornaviridae and is currently divided into 19 genotypes. HPeV-1 is the most prevalent genotype and most commonly causes gastrointestinal and respiratory disease. HPeV-3 is clinically the most important genotype due to its association with severe disease in younger infants, which may partly be explained by its distinct virological properties. In young infants, the typical clinical presentation includes fever, severe irritability, and rash, often leading to descriptions of “hot, red, angry babies.” Infants with severe central nervous system (CNS) infections are at an increased risk of long-term sequelae. Considering the importance of HPeV as a cause of severe viral infections in young infants, we recommend that molecular diagnostic techniques for early detection be included in the standard practice for the investigation of sepsis-like illnesses and CNS infections in this age group.

中文翻译：

---

人类腮腺病毒：越来越多的公认的婴幼儿败血症样疾病的病因[评论]

人副病毒（HPeV）在新生儿和幼儿中越来越被认为是潜在的严重病毒感染。HPeV属于Picornaviridae家族目前分为19个基因型。HPeV-1是最普遍的基因型，最常引起胃肠道和呼吸道疾病。HPeV-3在临床上是最重要的基因型，因为它与年幼婴儿的严重疾病有关，这在一定程度上可以用其独特的病毒学特性来解释。在幼儿中，典型的临床表现包括发烧，严重的烦躁和皮疹，通常导致描述为“热，红，生气的婴儿”。患有严重中枢神经系统（CNS）感染的婴儿长期后遗症的风险增加。考虑到HPeV作为导致婴幼儿严重病毒感染的原因的重要性，