Since the phase-out of pentaBDE in the early 2000s, replacement flame-retardant mixtures including Firemaster 550 (FM 550), Firemaster 600 (FM 600), and organophosphate aryl ester technical mixtures have been increasingly used to treat polyurethane foam in residential upholstered furniture. These mixtures contain isomers of isopropylated and tert-butylated triarylphosphate esters (ITPs and TBPPs), which have similar or greater neuro- and developmental toxicity compared to BDE 47 in high-throughput assays. Additionally, human exposure to ITPs and TBPPs has been demonstrated to be widespread in several recent studies; however, the relative composition of these mixtures has remained largely uncharacterized. Using available authentic standards, the present study quantified the contribution of individual ITP and TBPP isomers in four commercial flame retardant mixtures: FM 550, FM 600, an ITP mixture, and a TBPP mixture. Findings suggest similarities between FM 550 and the ITP mixture, with 2-isopropylphenyl diphenyl phosphate (2IPPDPP), 2,4-diisopropylphenyl diphenyl phosphate (24DIPPDPP), and bis(2-isopropylphenyl) phenyl phosphate (B2IPPPP) being the most prevalent ITP isomers in both mixtures. FM 600 differed from FM 550 in that it contained TBPP isomers instead of ITP isomers. These analytes were also detected and quantified in a house dust standard reference material, SRM 2585, demonstrating their environmental relevance.

中文翻译：

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几种商业阻燃剂混合物和房屋粉尘标准参考材料SRM 2585中异丙基和叔丁基磷酸三芳基酯（ITP和TBPP）异构体的表征

自从2000年代初淘汰五溴二苯醚以来，替代的阻燃混合物，包括Firemaster 550（FM 550），Firemaster 600（FM 600）和有机磷酸芳基酯技术混合物，已越来越多地用于处理住宅软垫家具中的聚氨酯泡沫。 。这些混合物包含异丙基和叔丁基的异构体-丁基化三芳基磷酸酯（ITP和TBPP），在高通量分析中，与BDE 47相比，具有相似或更高的神经和发育毒性。另外，在最近的几项研究中，人体暴露于ITP和TBPP的情况已被证明是广泛的。然而，这些混合物的相对组成基本上没有特征。使用可用的真实标准，本研究定量了四种商业阻燃混合物中的单个ITP和TBPP异构体的贡献：FM 550，FM 600，ITP混合物和TBPP混合物。研究结果表明，FM 550和ITP混合物之间存在相似性，分别与2-异丙基苯基二苯基磷酸酯（2IPPDPP），2,4-二异丙基苯基二苯基磷酸酯（24DIPPDPP），两种混合物中最常见的ITP异构体是双（2-异丙基苯基）苯基磷酸酯（B2IPPPP）。FM 600与FM 550的不同之处在于，它包含TBPP异构体而不是ITP异构体。在室内灰尘标准参考材料SRM 2585中也检测到了这些分析物并进行了定量分析，证明了它们与环境的相关性。