Trichomonas vaginalis is a major non-viral sexually-transmitted infection resulted into serious obstetrical and gynecological troubles. The increasing resistance to nitroimidazole therapy and recurrence makes it crucial to develop new drugs against trichomoniasis. Over the past few years, a large number of research articles highlighting the synthetic and natural product research to combat Trichomonas vaginalis have been published. Electronic databases were searched to collect all data from the year 2006 through June 2017 for anti-Trichomonas activity potential of synthetic and natural products. This review article put together the synthetic and natural product research to find out an effective metronidazole alternative to cure trichomoniasis.

阴道滴虫是主要的非病毒性传播感染，导致严重的产科和妇科疾病。对硝基咪唑治疗和复发的抵抗力不断增强，因此开发针对滴虫的新药至关重要。在过去的几年中，已经发表了大量强调合成和天然产物研究以对抗阴道毛滴虫的研究文章。搜索了电子数据库以收集从2006年到2017年6月的所有合成和天然产品抗滴虫活性潜力的数据。这篇综述文章综合了合成和天然产物的研究，以找到一种有效的甲硝唑替代品来治疗滴虫。