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Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice
Nature Neuroscience ( IF 25.0 ) Pub Date : 2017-11-13 , DOI: 10.1038/s41593-017-0021-0
Juliane Jaepel,Mark Hübener,Tobias Bonhoeffer,Tobias Rose

Experience-dependent plasticity in the mature visual system is widely considered to be cortical. Using chronic two-photon Ca2+ imaging of thalamic afferents in layer 1 of binocular visual cortex, we provide evidence against this tenet: the respective dorsal lateral geniculate nucleus (dLGN) cells showed pronounced ocular dominance (OD) shifts after monocular deprivation in adult mice. Most (86%), but not all, of dLGN cell boutons were monocular during normal visual experience. Following deprivation, initially deprived-eye-dominated boutons reduced or lost their visual responsiveness to that eye and frequently became responsive to the non-deprived eye. This cannot be explained by eye-specific cortical changes propagating to dLGN via cortico-thalamic feedback because the shift in dLGN responses was largely resistant to cortical inactivation using the GABAA receptor agonist muscimol. Our data suggest that OD shifts observed in the binocular visual cortex of adult mice may at least partially reflect plasticity of eye-specific inputs onto dLGN neurons.

中文翻译:

投射到初级视觉皮层的外侧膝状神经元在成年小鼠中表现出眼部优势可塑性

在成熟的视觉系统中,依赖于经验的可塑性被广泛认为是皮质的。使用慢性双光子Ca 2+成像的双眼视觉皮层1丘脑传入,我们提供了反对这一宗旨的证据:成年小鼠单眼剥夺后,各个背外侧膝状核(dLGN)细胞显示出明显的眼优势(OD)转移。在正常的视觉体验中,大多数(86%)但不是全部的dLGN细胞钮扣是单眼的。剥夺后,最初以剥夺眼睛为主的布顿减少或丧失了对那只眼睛的视觉反应能力,并经常对未剥夺的眼睛做出反应。这不能用通过丘脑反馈传播到dLGN的特定于眼睛的皮质变化来解释,因为dLGN反应的变化很大程度上抵抗了使用GABA A的皮质失活受体激动剂麝香酚。我们的数据表明,在成年小鼠双眼视觉皮层中观察到的OD移位可能至少部分反映了dLGN神经元上的眼睛特异性输入的可塑性。
更新日期:2017-11-13
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