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A dual-mode nanosensor based on the inner filter effect of gold nanoparticles on the fluorescence of CdS quantum dots for sensitive detection of arginine
Analytical Methods ( IF 3.1 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1039/c7ay01785e
Somayeh Khezri 1, 2, 3, 4, 5 , Morteza Bahram 1, 2, 3, 4, 5 , Naser Samadi 1, 2, 3, 4, 5
Affiliation  

In this work, we developed a low-cost, rapid, simple and sensitive analytical method for the visual and fluorescence detection of arginine based on the inner filter effect (IFE) of gold nanoparticles (AuNPs) on the fluorescence of CdS quantum dots (QDs). The proposed sensing system consists of AuNPs and fluorescent CdS QDs, where CdS QDs function as fluorometric reporters, and AuNPs serve a dual function as fluorescence quenchers and colorimetric reporters in the probe. The fluorescence of L-cysteine capped CdS QDs was significantly quenched by citrate-stabilized AuNPs via the IFE. Upon addition of arginine the IFE of AuNPs on the fluorescence of CdS QDs was weakened and the fluorescence intensity was recovered, since arginine could induce the aggregation of AuNPs accompanied by a color change from red to blue, which resulted in turn-on of the IFE-decreased fluorescence of CdS QDs. Under the optimum conditions, the fluorescence intensity of the CdS QDs/AuNP system was proportional to the concentration of arginine in the range of 7–215 μg L−1, with a detection limit of 2.4 μg L−1. The sensing platform had been used for arginine detection in human serum and arginine injection samples with satisfactory results.

中文翻译:

基于金纳米粒子对CdS量子点荧光的内滤效应的双模式纳米传感器,用于精氨酸的灵敏检测

在这项工作中,我们基于金纳米颗粒(AuNPs)对CdS量子点(QDs)荧光的内滤效应(IFE),开发了一种用于精氨酸的视觉和荧光检测的低成本,快速,简单而灵敏的分析方法)。拟议的传感系统由AuNP和荧光CdS QD组成,其中CdS QD充当荧光报告分子,AuNP在探针中担当双重荧光猝灭剂和比色报告分子。柠檬酸盐稳定的AuNPs通过L-半胱氨酸封端的CdS QD的荧光显着淬灭IFE。添加精氨酸后,CdS QDs荧光上的AuNPs的IFE减弱,荧光强度得以恢复,因为精氨酸可诱导AuNPs聚集,同时颜色由红色变为蓝色,从而导致IFE开启。 -降低了CdS QD的荧光。在最佳条件下,CdS QDs / AuNP系统的荧光强度与精氨酸浓度在7–215μgL -1范围内成正比,检出限为2.4μgL -1。该传感平台已用于人血清和精氨酸注射液样品中的精氨酸检测,结果令人满意。
更新日期:2017-11-13
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