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Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-11 , DOI: 10.1016/j.tet.2017.11.026
Zhi-Mao Zhang , Yu-Jue Gao , Jian-Mei Lu

Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes.



中文翻译:

N-杂环卡宾-Pd(II)配合物的合成及其在芳基氯化物的布赫瓦尔德-哈特维格胺胺化反应中的催化活性

使用2-吡啶甲酸作为辅助配体的新型N-杂环卡宾-钯(II)配合物已在温和条件下成功开发。最初已经在仲胺和伯胺与芳基氯化物的布赫瓦尔德-哈特维格胺胺化中测试了它们在有机合成中的催化活性。可以容忍两种底物上的各种取代基,从而以良好或几乎定量的产率提供所需的偶联产物。最小催化剂负载量可以为0.01 mol%,这意味着它们在工业过程中的潜在应用。

更新日期:2017-11-11
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