Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing. Impaired regulation of glucose and the resultant hyperglycemia are major threats to the health of individuals in modern societies especially given the rapidly rising prevalence affecting an increasing number of men in their reproductive years. Consequently, diabetes-induced hyperglycemia is likely to contribute to a decline in global birth rates especially in those societies with a high diabetic prevalence.

中文翻译：

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糖尿病引起的高血糖损害男性生殖功能：系统评价

高血糖症可能是由于胰腺β细胞丢失或功能下降导致胰岛素分泌减少所致，也可能是由于胰岛素抵抗和不同程度的胰岛素分泌不足所致，从而导致糖尿病和相关合并症。迄今为止，已有几篇评论论述了与糖尿病相关的男性不育症，但大多数评论都集中在代谢综合征如何导致男性不育症的下降上。但是，关于糖尿病诱发的高血糖如何损害男性生育力的全面概述尚不存在。葡萄糖调节不良和由此产生的高血糖症是现代社会中个人健康的主要威胁，特别是考虑到流行率迅速上升影响了生育年龄段中越来越多的男性。所以，