Peripheral artery disease is a systemic atherothrombotic disease in which plaque builds up in the arteries that carry blood to the limbs. If severe enough, impaired blood flow can cause critical limb ischaemia, which presents as resting pain, ulceration, or gangrene, and might require a limb amputation in the most extreme cases.¹ People with peripheral artery disease often have plaque in other arterial beds, and thus are at increased risk for myocardial infarction, ischaemic stroke, and cardiovascular death.

中文翻译：

---

外周动脉疾病的抗血栓治疗

周围动脉疾病是一种系统性动脉粥样硬化性疾病，其中斑块积聚在将血液带到四肢的动脉中。如果足够严重，血流受损会导致严重的肢体缺血，表现为静息疼痛，溃疡或坏疽，在最极端的情况下可能需要截肢。¹患有外周动脉疾病的人经常在其他动脉床上有斑块，因此患心肌梗塞，缺血性中风和心血管死亡的风险增加。