Moving our society towards a bioeconomy requires efficient and sustainable microbial production of chemicals and fuels. Rhodotorula (Rhodosporidium) toruloides is a yeast that naturally synthesizes substantial amounts of specialty chemicals and has been recently engineered to (i) enhance its natural production of lipids and carotenoids, and (ii) produce novel industrially relevant compounds. The use of R. toruloides by companies and research groups has exponentially increased in recent years as a result of recent improvements in genetic engineering techniques and the availability of multiomics information on its genome and metabolism. This review focuses on recent engineering approaches in R. toruloides for bioproduction and explores its potential as a biotechnological chassis.

要使我们的社会朝着生物经济迈进，就需要高效，可持续地生产化学药品和燃料。Rhodotorula（Rhodosporidium）toruloides是一种酵母，可以自然地合成大量的特种化学品，并且最近经过了工程改造以（i）增强其天然生产的脂质和类胡萝卜素，以及（ii）生产新型的工业相关化合物。采用R.孢酵母的公司和研究小组在最近几年呈指数级增长作为基因工程技术的最新改进的结果，并对其基因组和代谢multiomics信息的可用性。这篇综述着眼于R. toruloides的最新工程方法 用于生物生产，并探索其作为生物技术底盘的潜力。