We demonstrate the realization of the first label-free optical biosensor based on the room temperature luminescence of silicon nanowires (NWs) tested for the selective detection of C-reactive protein in human serum. High aspect ratio Si NW arrays used as sensing interface, are synthesized by a fast, low cost and Si industrially compatible approach. Si NW optical biosensors are fast and offer a broad concentration dynamic range that can be tuned according to different applications. Moreover, the platform is endowed with a high selectivity toward the target analyte and a sensitivity down to the fM limit of detection, opening the route toward noninvasive analysis in biofluids such as saliva.

中文翻译：

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新一代超灵敏的无标记光学硅纳米线生物传感器

我们演示了基于硅纳米线（NWs）的室温发光测试的第一个无标记光学生物传感器的实现，该纳米线经测试可选择性检测人血清中的C反应蛋白。高长宽比的Si NW阵列用作传感接口，是通过一种快速，低成本且与Si工业兼容的方法合成的。Si NW光学生物传感器速度快，可提供广泛的浓度动态范围，可以根据不同的应用进行调整。此外，该平台具有对目标分析物的高选择性和低至fM检测极限的灵敏度，为在诸如唾液等生物流体中进行非侵入性分析开辟了道路。