Excessive use of antibiotics in breeding industry leads to accumulation of antibiotic residuals and antibiotic resistance genes (ARGs) in environment from improperly treated livestock excrements. Four commonly used veterinary antibiotics including chlortetracycline (CTC), sulfamerazine (SMZ), enrofloxacin (ENR) and erythromycin (ERY) were monitored in the swine manure composting. Co-resistance and cross-resistance effects among relative ARGs, correlations between ARGs and bacterial community under multiple antibiotics residual during the composting were investigated in this research. With CTC addition up to 20 mg/kg, more than 99% of CTC removal was achieved after composting, and most of the other antibiotics can be thoroughly removed as well. The variations in ARGs during the composting were strongly correlated to the compositions of the microbial community, Bacteroides and Sporosarcina were main ARGs carriers in the thermophlic phase. Clostridium Ⅺ, Clostridium sensu stricto, and Pseudoxanthomonas, might spread ARGs in cooling and maturing stage. Most of the tested ARGs in swine manure can be effectively reduced through composting, thus makes the compost products safe for soil fertilization.

在养殖业中过度使用抗生素会导致未经处理的牲畜粪便在环境中积累抗生素残留和抗生素抗性基因（ARG）。在猪粪堆肥中监测了四种常用的兽用抗生素，包括金霉素（CTC），磺胺嘧啶（SMZ），恩诺沙星（ENR）和红霉素（ERY）。本研究研究了堆肥过程中多种残留抗生素在相对ARGs之间的共抗性和交叉抗性效应，ARGs与细菌群落之间的相关性。通过添加高达20 mg / kg的四氯化碳，堆肥后可去除超过99％的四氯化碳，并且大多数其他抗生素也可以被彻底清除。拟杆菌属中的拟杆菌属和孢子菌是主要的ARGs携带者。Ⅺ梭菌，梭状芽孢杆菌属狭义和Pseudoxanthomonas，可能会蔓延ARG游戏的冷却和成熟阶段。可以通过堆肥有效地减少猪粪中大多数已测试的ARGs，从而使堆肥产品可安全施用于土壤。