We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au₃Ag₁NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au₃Ag₁NPs which afforded decreased activity) in comparison to complex 1.

中文翻译：

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锌酞菁纳米共轭物与谷胱甘肽加帽的Au和Au ₃ Ag ₁纳米粒子连接的光物理化学性质和光动力治疗活性的评价

我们报告了谷胱甘肽加帽的金（AuNPs–GSH）和金–银（Au ₃ Ag ₁ NPs–GSH）纳米颗粒的合成及其通过酰胺键形成的与锌单羧基苯氧基酞菁（1）的共价连接。评估了复合物及其纳米共轭物的光物理化学性质和光动力疗法（PDT）活性。缀合物，得到改善的三线态和单线态氧量子产率以及PDT活性（除了1个-Au ₃的Ag ₁纳米粒子，这提供活性降低）相比，复杂1。