Meroterpenoid natural products are important bioactive molecules with broad distribution throughout nature. In Streptomyces bacteria, naphthoquinone-based meroterpenoids comprise a simple yet structurally fascinating group of natural product antibiotics that are enzymatically constructed through a series of asymmetric alkene and arene halofunctionalization reactions. This account article highlights our discovery and characterization of a group of vanadium-dependent chloroperoxidase enzymes that catalyze halogen-assisted cyclization and rearrangement reactions and have inspired biomimetic syntheses of numerous meroterpenoid natural products.

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类萜生物合成中的不对称烯烃和芳烃卤代官能化反应

类萜天然产物是重要的生物活性分子，在自然界中广泛分布。在链霉菌中，基于萘醌的半萜类化合物包含一组简单但结构迷人的天然产物抗生素，它们是通过一系列不对称烯烃和芳烃卤代官能化反应以酶法构建的。这篇文章重点介绍了我们对一组钒依赖性氯过氧化物酶的发现和表征，这些酶催化卤素辅助环化和重排反应，并启发了许多类萜天然产物的仿生合成。