Structurally diverse novel 1,4-benzodiazepine analogues related to selective CCKA antagonist MK-329, and CCKB antagonists L-365,260 and YM022 are prepared via palladium-catalyzed three component domino reactions involving allenylation-carbonylation-anion capture in one-pot cascade protocol in good to excellent yields.

中文翻译：

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通过钯催化三组分级联反应设计和合成新型1,4-苯并二氮杂卓替代品作为潜在的CCKA和CCKB拮抗剂

结构上新颖的与选择性CCKA拮抗剂MK-329和CCKB拮抗剂L-365,260和YM022有关的新型1,4-苯并二氮杂analogue类似物是通过钯催化的一锅级联方案中的烯丙基化-羰基化-阴离子捕获的三组分多米诺反应制备的。好到极好的产量。