As a characteristic trait of most tumor types, metastasis is the major cause of the death of patients. In this study, a photothermal agent based on gold nanorod is coated with metal (Gd³⁺)‐organic (polyphenol) network to realize combination therapy for metastatic tumors. This nanotheranostic system significantly enhances antitumor therapeutic effects in vitro and in vivo with the combination of photothermal therapy (PTT) and chemotherapy, also can remarkably prevent the invasion and metastasis due to the presence of polyphenol. After the treatment, an 81% decrease in primary tumor volumes and a 58% decrease in lung metastasis are observed. In addition, the good performance in magnetic resonance imaging, computerized tomography, and photothermal imaging of the nanotheranostic system can realize image‐guided therapy. The multifunctional nanotheranostic system will find a great potential in diagnosis and treatment integration in tumor treatments, and broaden the applications of PTT treatment.

中文翻译：

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金属-多酚网络涂层的纳米治疗系统用于转移性肿瘤治疗。

作为大多数肿瘤类型的特征，转移是患者死亡的主要原因。在这项研究中，基于金纳米棒的光热剂被金属（Gd ³⁺）（多酚）网络以实现转移性肿瘤的联合治疗。结合光热疗法（PTT）和化学疗法，这种纳米治疗系统显着增强了体内和体外的抗肿瘤治疗效果，还可以显着防止由于多酚的存在而引起的侵袭和转移。治疗后，观察到原发肿瘤体积减少了81％，肺转移减少了58％。此外，在纳米热成像系统的磁共振成像，计算机断层扫描和光热成像方面，良好的性能可以实现图像引导治疗。多功能纳米治疗系统将在肿瘤治疗的诊断和治疗整合中找到巨大的潜力，并扩大PTT治疗的应用范围。