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Paving the Path toward Porcine Organs for Transplantation
The New England Journal of Medicine ( IF 158.5 ) Pub Date : 2017-11-08 , DOI: 10.1056/nejmcibr1710853
Joachim Denner

The pig heart is a candidate organ for xenotransplantation, but endogenous retroviruses (ERVs) in the pig genome can infect human cells in vitro, raising the specter of zoonotic infection. A recent report describes the generation of healthy pigs free of replication-competent ERVs.

中文翻译:

为猪器官移植铺平道路

猪心脏是异种移植的候选器官,但是猪基因组中的内源性逆转录病毒(ERV)可以在体外感染人细胞,从而增加了人畜共患感染的可能性。最近的一份报告描述了没有复制能力的ERV的健康猪的产生。
更新日期:2017-11-09
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