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Cover Feature: Selective One‐Pot Two‐Step C−C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts (ChemCatChem 21/2017)
ChemCatChem ( IF 4.5 ) Pub Date : 2017-11-09 , DOI: 10.1002/cctc.201701689
Francisco G. Cirujano 1 , Elena López-Maya 2 , Marleny Rodríguez-Albelo 2 , Elisa Barea 2 , Jorge A. R. Navarro 2 , Dirk E. De Vos 1
Affiliation  

The Cover Feature shows a tandem two‐step C−C bond formation catalyzed by a new copper ion exchanged metal‐organic framework (MOF) with high basicity and stability. In their Communication, F. G. Cirujano, E. López‐Maya et al. describe how to selectively direct the tandem C−C bond formation towards the desired pharmaceutical intermediate by tuning the basicity of defective nickel pyrazolate frameworks, through ion exchange with Cu(II) cations. The presence of copper ions at the nickel‐oxo clusters and the adequate basicity of this MOF promote the selective condensation and alkylation steps, directing the benzaldehyde starting product towards the substituted indole and minimizing the formation of by‐products. More information can be found in the Communication by F. G. Cirujano, E. López‐Maya et al. on page 4019 in Issue 21, 2017 (DOI: 10.1002/cctc.201700784).
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中文翻译:

封面文章:使用具有轻度碱度的金属有机骨架作为多相催化剂的选择性一锅两步C-C键形成(ChemCatChem 21/2017)

封面功能显示了由具有高碱度和稳定性的新型铜离子交换金属有机骨架(MOF)催化的串联式两步C-C键形成。在他们的交流中,F。G. Cirujano,E。López‐Maya等。描述了如何通过与铜(II)阳离子进行离子交换来调节有缺陷的吡唑酸镍骨架的碱度,从而选择性地将串联C-C键的形成引向所需的药物中间体。镍-氧代簇上铜离子的存在和该MOF的适度碱性促进了选择性缩合和烷基化步骤,将苯甲醛起始产物引向取代的吲哚,并最大程度地减少了副产物的形成。有关更多信息,请参见F. G. Cirujano,E。López‐Maya等人的通讯。上2017年第21期,第4019页(DOI:10.1002 / cctc.201700784)。
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更新日期:2017-11-09
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