Treatment of quinolines bearing methyl, fluoro, chloro, bromo, acetyl, methoxycarbonyl, trifluoromethyl, or cyano groups with Na₂S₂O₈ in a mixture of methanol and water at 70 °C for 4 h gave the corresponding hydroxymethylated compounds in good to moderate yields. The hydroxymethyl group of the product was transformed into aldehyde, ester, amide, aminomethyl, cyano, and tetrazole groups.

中文翻译：

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Na2S2O8通过自由基途径对喹啉进行羟甲基化

在甲醇和水的混合物中，用Na ₂ S ₂ O ₈在70°C下处理带有甲基，氟，氯，溴，乙酰基，甲氧基羰基，三氟甲基或氰基的喹啉4小时，得到相应的羟甲基化化合物中等产量。产物的羟甲基被转化为醛，酯，酰胺，氨甲基，氰基和四唑基。