Phytochemical investigation of the alkaloid extract of Palicourea sessilis by LC-HRMS/MS using molecular networking and an in silico MS/MS fragmentation approach suggested the presence of several new monoterpene indole alkaloids. These compounds were isolated by semipreparative HPLC, and their structures confirmed by means of HRMS, NMR, and ECD measurements as 4-N-methyllyaloside (3), 4-N-methyl-3,4-dehydrostrictosidine (4), 4β-hydroxyisodolichantoside (6), and 4α-hydroxyisodolichantoside (7), as well as the known alkaloids alline (1), N-methyltryptamine (2), isodolichantoside (5), and 5-oxodolichantoside (8). In addition, the acetylcholinesterase inhibitory activity of the compounds was evaluated up to 50 μM.

中文翻译：

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有针对性地从芝麻油中分离出单萜吲哚生物碱

LC-HRMS / MS使用分子网络和计算机MS / MS片段化方法对芝麻木生物碱提取物的植物化学研究表明，存在几种新的单萜吲哚生物碱。这些化合物通过半制备型HPLC分离，并且它们的结构确认通过HRMS的手段，NMR和ECD测量值作为4- ñ -methyllyaloside（3），4- ñ -甲基-3,4- dehydrostrictosidine（4），4β-hydroxyisodolichantoside （6）和4α-羟基异甘露糖苷（7），以及已知的生物碱烯丙胺（1），N-甲基色胺（2），异碘甘露糖苷（（5）和5-氧代寡糖苷（8）。另外，评估化合物的乙酰胆碱酯酶抑制活性至多50μM。