Lynchpins comprising α-silyl amides have been validated for type I anion relay chemistry (ARC) to permit ready access to γ-ketoamides. Importantly, the ARC protocol can be run at ambient temperature without the need of additional reagents to trigger the [1,4] Brook rearrangement.

中文翻译：

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α-甲硅烷基酰胺：用于I型阴离子中继化学的有效双功能Lynchpins

包含α-甲硅烷基酰胺的Lynchpins已通过I型阴离子中继化学（ARC）的验证，可以立即使用γ-酮酰胺。重要的是，ARC协议可以在环境温度下运行，而无需其他试剂即可触发[1,4] Brook重排。