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Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7ob02461d
Yaqi Yang 1, 2, 3, 4 , Zihang Ye 1, 2, 3, 4 , Xu Zhang 4, 5, 6, 7, 8 , Yipeng Zhou 1, 2, 3, 4 , Xiantao Ma 1, 2, 3, 4, 5 , Hongen Cao 4, 5, 6, 7, 8 , Huan Li 1, 2, 3, 4 , Lei Yu 4, 5, 6, 7, 8 , Qing Xu 1, 2, 3, 4, 5
Affiliation  

Alcohols can be efficiently converted into the useful thioethers by a transition metal- and base-free dehydrative S-alkylation reaction with thiols or disulfides by employing alkyl halides as the effective catalyst. This simple and efficient method is a green and practical way for the preparation of thioethers, as it tolerates a wide range of substrates such as aryl and alkyl thiols, as well as benzylic, allylic, secondary, tertiary, and even the less reactive aliphatic alcohols.

中文翻译:

卤代烷催化的醇高效硫醇脱水烷基化反应

通过使用烷基卤化物作为有效催化剂,通过与硫醇或二硫化物的无过渡金属和碱的脱水S-烷基化反应,可以将醇有效地转化为有用的硫醚。这种简单有效的方法是制备硫醚的绿色实用方法,因为它可以耐受多种底物,例如芳基和烷基硫醇,以及苄基,烯丙基,仲,叔,甚至反应性较差的脂肪醇。
更新日期:2017-11-08
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