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CITU: A Peptide and Decarboxylative Coupling Reagent
Organic Letters ( IF 5.2 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1021/acs.orglett.7b03121
Justine N. deGruyter 1 , Lara R. Malins 1 , Laurin Wimmer 1 , Khalyd J. Clay 1 , Javier Lopez-Ogalla 1 , Tian Qin 1 , Josep Cornella 1 , Zhiqing Liu 2 , Guanda Che 2 , Denghui Bao 2 , Jason M. Stevens 3 , Jennifer X. Qiao 4 , Martin P. Allen 4 , Michael A. Poss 4 , Phil S. Baran 1
Affiliation  

Tetrachloro-N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (CITU) is disclosed as a convenient and economical reagent for both acylation and decarboxylative cross-coupling chemistries. Within the former set of reactions, CITU displays reactivity similar to that of common coupling reagents, but with increased safety and reduced cost. Within the latter, increased yields, more rapid conversion, and a simplified procedure are possible across a range of reported decarboxylative transformations.

中文翻译:

CITU:肽和脱羧偶联试剂

Ç hloro- Ñ -hydroxyphthal酰胺etramethyl ù ronium六氟磷酸盐(CITU)中公开了作为用于既酰化和脱羧交叉偶联化学方便和经济的试剂。在前一组反应中,CITU显示出与普通偶联剂相似的反应性,但具有更高的安全性并降低了成本。在后者中,在一系列报道的脱羧转化中,可能增加产率,更快地转化和简化程序。
更新日期:2017-11-08
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