Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain.

中文翻译：

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Pleiokomenines A和B：与亚甲基拴在一起的二聚Aspidofractinine生物碱

从苦竹的茎皮中分离出苦苦碱A和B（1和2），即通过亚甲基桥连接的二聚化的Aspidofractinine生物碱的第一个实例。通过光谱分析和多古皮碱（3）的半合成衍生化以及由三氟甲磺酸scan介导的甲醛当量的结合，阐明了它们的结构。Pleiokomenines A（1）和B（2）在微摩尔范围内对FcB1菌株显示适度的抗血浆活性。