A highly regioselective method to access 5-amido fully substituted 1,2,3-triazoles by iridium-catalyzed azide–ynamide cycloaddition under mild, air, aqueous, and bioorthogonal conditions is reported. The excellent regioselectivities may derive from the strong coordination between the carbonyl oxygen of ynamide and the π-acidic iridium. Since the iridium ion is insensitive to oxygen/water and exhibits low cytotoxicity, it could catalyze this reaction in both organic and biological environments efficiently. Preparation in gram-scale and application in carbohydrates highlight this method.

中文翻译：

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在温和，空气，水和生物正交条件下，铱催化的高区域选择性叠氮化物-亚酰胺环加成反应可得到5-氨基完全取代的1,2,3-三唑

据报道，在温和的，空气，水和生物正交条件下，通过铱催化的叠氮化物-酰胺基环加成反应可得到5-氨基完全取代的1,2,3-三唑的高度区域选择性方法。优异的区域选择性可以源自于酰胺的羰基氧与π-酸性铱之间的强配位。由于铱离子对氧气/水不敏感并且显示出低的细胞毒性，因此它可以在有机和生物环境中有效地催化该反应。以克为单位的制备和在碳水化合物中的应用突出了该方法。