Supramolecular materials composed of proteins and peptides have been receiving considerable attention toward a range of diseases and conditions from vaccines to drug delivery. Owing to the relative newness of this class of materials, the bulk of work to date has been preclinical. However, examples of approved treatments particularly in vaccines, dentistry, and hemostasis demonstrate the translational potential of supramolecular polypeptides. Critical milestones in the clinical development of this class of materials and currently approved supramolecular polypeptide therapies are described in this study. Additional examples of not-yet-approved materials that are steadily advancing toward clinical use are also featured. Spherical assemblies such as virus-like particles, designed protein nanoparticles, and spherical peptide amphiphiles are highlighted, followed by fiber-forming systems such as fibrillizing peptides, fiber-forming peptide-amphiphiles, and filamentous bacteriophages.

中文翻译：

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仿生肽和蛋白质组装体的临床转化进展。

由蛋白质和肽组成的超分子材料在从疫苗到药物输送的一系列疾病和病症方面受到了相当多的关注。由于此类材料相对较新，迄今为止的大部分工作都是临床前的。然而，已批准治疗的例子，特别是在疫苗、牙科和止血方面，证明了超分子多肽的转化潜力。本研究描述了此类材料和目前批准的超分子多肽疗法的临床开发的关键里程碑。还介绍了正在稳步推进临床使用的尚未批准材料的其他示例。重点介绍了病毒样颗粒、设计的蛋白质纳米颗粒和球形肽两亲物等球形组装体，然后是纤维形成系统，如纤维化肽、纤维形成肽两亲物和丝状噬菌体。