Type 2 immune responses have evolved to sense and respond to large, non-replicating infections or non-microbial noxious compounds in tissues. The development of these responses therefore depends upon highly coordinated and tightly regulated tissue-residing cellular sensors and responders. Multiple exposure to type 2 helper T cell (Th2)-inducing stimuli further enhances both the diversity and potency of the response. This review discusses advances in our understanding of the interacting cellular subsets that comprise both primary and secondary type 2 responses. Current knowledge regarding type 2 immune responses in the lung are initially presented and are then contrasted with what is known about the small intestine. The studies described portray an immune response that depends upon well-organized tissue structures, and suggest their modulation as a therapeutic strategy.

中文翻译：

---

2型免疫反应哨兵

2型免疫应答已发展为可感知并响应组织中的大型非复制型感染或非微生物有害化合物。因此，这些反应的发展取决于高度协调和严格调节的驻留在组织中的细胞传感器和反应器。多次暴露于2型辅助T细胞（Th2）诱导的刺激进一步增强了反应的多样性和效力。这篇综述讨论了我们对包括主要和次要2型反应的相互作用细胞亚群的理解的进展。首先介绍了有关肺中2型免疫反应的当前知识，然后将其与有关小肠的知识进行了对比。描述的研究描述了依赖于组织良好的组织结构的免疫应答，