Finding new multicomponent crystal forms of commercially available pharmaceuticals is important, as they represent a straightforward way to drastically influence the solid-state properties of a drug. The antibiotic 4-aminosalicylic acid (ASA) is known to exist in several multicomponent crystal forms, and in this work we expand the world of ASA cocrystals and salts by reporting new crystalline forms comprising diazabicyclo[2.2.2]octane (DABCO), and caffeine. All species were characterized by X-ray single crystal, powder diffraction, and thermal behavior. This study contributes to the rationalization of preferred functional groups for the synthesis of 4-aminosalicylic acid new multicomponent crystal forms and highlights the relevance of the reaction conditions in the achievement of those forms.

中文翻译：

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扩大抗生素4-氨基水杨酸的多组分晶体形式的库：结晶条件的影响

寻找可商购的药物的新的多组分晶体形式很重要，因为它们代表了一种直接影响药物固态特性的直接方法。已知抗生素4-氨基水杨酸（ASA）以几种多组分晶体形式存在，在这项工作中，我们通过报告包含二氮杂双环[2.2.2]辛烷（DABCO）的新晶体形式，扩展了ASA共晶体和盐的领域。咖啡因。所有种类的特征在于X射线单晶，粉末衍射和热行为。这项研究有助于合成4-氨基水杨酸新的多组分晶体形式的优选官能团的合理化，并强调了反应条件对实现这些形式的重要性。