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Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
Nature Chemistry ( IF 21.8 ) Pub Date : 2017-11-06 , DOI: 10.1038/nchem.2878
Clémentine Gibard , Subhendu Bhowmik , Megha Karki , Eun-Kyong Kim , Ramanarayanan Krishnamurthy

Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions, Published online: 06 November 2017; doi:10.1038/nchem.2878

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Phosphorylation of (pre)biological molecules in water has been a long-sought goal in prebiotic chemistry. Now, it has been demonstrated that diamidophosphate phosphorylates nucleosides, amino acids and glycerol/fatty acids in aqueous medium, while simultaneously leading to higher-order structures such as oligonucleotides, peptides and liposomes in the same reaction mixture.

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中文翻译:

潜在益生元条件下水中的磷酸化,低聚和自组装

潜在益生元条件下水中的磷酸化,低聚和自组装

潜在的益生元条件下水中的磷酸化,低聚和自组装,在线发布:2017年11月6日;doi:10.1038 / nchem.2878

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水中(生物)分子的磷酸化一直是益生元化学中一个长期追求的目标。现在,已经证明二氨基磷酸酯使水性介质中的核苷,氨基酸和甘油/脂肪酸磷酸化,同时在同一反应混合物中同时导致更高级别的结构,例如寡核苷酸,肽和脂质体。

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更新日期:2017-11-06
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