A model compound, ethyl 3-acetamido-3-deoxy-1-O-phosphono-β-d-psicofuranosyl sulfone, was synthesized as a potential N-Acetylglucosaminyltransferase inhibitor. However, a biochemical assay did not confirm the anticipated inhibition. Further modifications of the model compound are considered based on molecular modeling.

中文翻译：

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β-d-呋喃呋喃糖基砜的合成及对N-乙酰氨基葡萄糖氨基转移酶I的抑制活性评价

合成了模型化合物3-乙酰氨基-3-脱氧-1- O-膦酰基-β - d - psi呋喃呋喃糖基砜，作为潜在的N-乙酰氨基葡萄糖氨基转移酶抑制剂。但是，生化分析未确认预期的抑制作用。基于分子建模，可以考虑对模型化合物进行进一步的修改。