The convenient preparation of 1-C-propargyl-imino-l-arabinitol derivatives coupled by a triazole tether to various aromatic and heteroaromatic groups is reported. These structures, which can be considered to be simplified mimics of UDP-Galf, the substrate of GlfT2, a galactofuranosyltransferase present in mycobacteria, were evaluated as inhibitors of the enzyme and were found to have significant activity.

中文翻译：

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三唑连接的氨基糖和芳香系统作为简化的UDP-半乳糖模拟物：合成和初步评估作为半乳糖转移酶抑制剂。

已经报道了通过三唑系链与各种芳族和杂芳族基团偶联的1 - C-炔丙基-亚氨基-1-阿拉伯糖醇衍生物的方便制备。这些结构中，其可以被认为是简化的UDP-Gal的模拟物˚F，GlfT2，存在于分枝杆菌galactofuranosyltransferase的基板，进行评价作为酶的抑制剂，并发现有显著活性。