Houttuynoid M (1), a new houttuynoid, and the related known compound houttuynoid A (2) were isolated from Houttuynia cordata. Their structures were defined using NMR data analysis, HR-MSⁿ experiment, and chemical derivatization. Houttuynoid M is the first example of a houttuynoid with a bis-houttuynin chain tethered to a flavonoid core. A putative biosynthetic pathway of houttuynoid M (1) is proposed. The anti-herpes simplex virus (anti-HSV) activities of 1 and 2 (IC₅₀ values of 17.72 and 12.42 μM, respectively) were evaluated using a plaque formation assay with acyclovir as the positive control.

中文翻译：

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Houttuynoid M，一种来自鱼腥草的抗HSV活性Houttuynoid，其特征在于将双鱼腥草素链束缚在类黄酮核心上

鱼腥草M（1），一个新的鱼腥草，和相关的已知化合物鱼腥草A（2）是从鱼腥草中分离出来的。使用NMR数据分析，HR-MS ⁿ实验和化学衍生化定义了它们的结构。Houttuynoid M是Houttuynoidoid的第一个例子，其双-Houttuynynin链拴在类黄酮核心上。拟南芥M（1）的假定的生物合成途径。使用以阿昔洛韦为阳性对照的噬斑形成测定法评估了1和2的抗单纯疱疹病毒（anti-HSV）活性（IC ₅₀值分别为17.72和12.42μM）。