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Direct Allylic Amination of Allylic Alcohol Catalyzed by Palladium Complex Bearing Phosphine–Borane Ligand
Organic Letters ( IF 5.2 ) Pub Date : 2017-11-02 00:00:00 , DOI: 10.1021/acs.orglett.7b03023
Goki Hirata 1 , Hideaki Satomura 1 , Hidenobu Kumagae 1 , Aika Shimizu 1 , Gen Onodera 1 , Masanari Kimura 1
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The direct electrophilic, nucleophilic, and amphiphilic allylations of allylic alcohol by use of a palladium catalyst and organometallic reagents such as organoborane and organozinc has been developed. The phosphine–borane compound works as the effective ligand for palladium-catalyzed direct allylic amination of allylic alcohol. Thus, with secondary amines, the reaction was completed in only 1 h, even at room temperature.

中文翻译:

含膦-硼烷配体的钯配合物催化的烯丙醇直接烯丙基胺化

已经开发了通过使用钯催化剂和有机金属试剂例如有机硼烷和有机锌的烯丙基醇的直接亲电子,亲核和两亲烯丙基化。膦-硼烷化合物可作为钯催化的烯丙基醇直接烯丙基胺化的有效配体。因此,使用仲胺,即使在室温下,反应也仅需1小时即可完成。
更新日期:2017-11-02
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