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Comparative pathogenesis of rabies in bats and carnivores, and implications for spillover to humans.
The Lancet ( IF 168.9 ) Pub Date : 2018-Apr-01 , DOI: 10.1016/s1473-3099(17)30574-1
Lineke Begeman , Corine GeurtsvanKessel , Stefan Finke , Conrad M Freuling , Marion Koopmans , Thomas Müller , Tom J H Ruigrok , Thijs Kuiken

Bat-acquired rabies is becoming increasingly common, and its diagnosis could be missed partly because its clinical presentation differs from that of dog-acquired rabies. We reviewed the scientific literature to compare the pathogenesis of rabies in bats and carnivores-including dogs-and related this pathogenesis to differences in the clinical presentation of bat-acquired and dog-acquired rabies in human beings. For bat-acquired rabies, we found that the histological site of exposure is usually limited to the skin, the anatomical site of exposure is more commonly the face, and the virus might be more adapted for entry via the skin than for dog-acquired rabies. These factors could help to explain several differences in clinical presentation between individuals with bat-acquired and those with dog-acquired rabies. A better understanding of these differences should improve the recording of a patient's history, enable drawing up of a more sophisticated list of clinical characteristics, and therefore obtain an earlier diagnosis of rabies after contact with a bat or carnivore that has rabies.

中文翻译:

蝙蝠和食肉动物中狂犬病的比较发病机制及其对人类溢出的影响。

蝙蝠获得性狂犬病变得越来越普遍,由于其临床表现不同于狗获得性狂犬病,其诊断可能会被部分遗漏。我们回顾了科学文献,以比较蝙蝠和食肉动物(包括狗)中狂犬病的发病机理,并将这种发病机理与人类中蝙蝠获得性和狗获得性狂犬病的临床表现差异相关。对于蝙蝠获得性狂犬病,我们发现暴露的组织学部位通常仅限于皮肤,暴露的解剖部位更常见于面部,并且与狗获得性狂犬病相比,该病毒可能更适合通过皮肤进入。这些因素可以帮助解释蝙蝠获得性狂犬病患者与狗获得性狂犬病患者在临床表现方面的几种差异。
更新日期:2018-03-22
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