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Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete
Organic Letters ( IF 5.2 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1021/acs.orglett.7b03113
Shi Ying Ma 1 , Yong Sheng Xiao 1 , Bo Zhang 1 , Fen Li Shao 1 , Zhi Kai Guo 2 , Juan Juan Zhang 1 , Rui Hua Jiao 1 , Yang Sun 1 , Qiang Xu 1 , Ren Xiang Tan 1, 3 , Hui Ming Ge 1
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Two novel enediyne-derived natural products, amycolamycins A and B (1 and 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line.

中文翻译:

蝗虫相关放线菌中的两种烯对炔衍生物Amycolamycins A和B

两种与蝗虫有关的放线菌Amycolatopsis sp。鉴定了两个新的烯二炔衍生的天然产物,阿霉素A和B(12)。HCa4。霉菌素A和B含有独特的2-(环戊[a]茚基-5-基)环氧乙烷核心,怀疑是烯二炔聚酮化合物的生物合成来源。对acm生物合成基因簇的测序和分析使我们能够提出12的生物合成途径。此外,amycolamycin A(1)是选择性的细胞毒性的M231乳腺癌细胞系。
更新日期:2017-11-01
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