Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today’s crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise control of the crystal size and shape distribution, as well as polymorphic composition. Tubular crystallizers utilizing segmented flow such as the one presented in our work can provide plug flow characteristics, fast heating and cooling, allowing for rapid changes of the supersaturation. This makes them superior for crystal engineering over common crystallizers. Characterization of particle transport, however, revealed that careful selection of process parameters, such as tubing diameter, flow rates, solvents, etc., is crucial to achieve the full benefits of such reactors.

中文翻译：

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连续活塞流结晶器中的晶体工程

尺寸，形状和多晶型是晶体颗粒的关键属性，它们代表了当今结晶工艺设计的主要重点。这项工作演示了如何通过有助于快速温度循环的管状结晶器有效地调节溶液中的晶体性能。受控的晶体生长，溶解和二次成核作用可以精确控制晶体的大小和形状分布以及多晶型物的组成。利用分段流动的管状结晶器，例如我们的工作中提出的结晶器，可以提供塞流特性，快速加热和冷却，并允许过饱和度的快速变化。这使得它们在晶体工程方面优于普通结晶器。然而，颗粒传输的表征