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PARPi focus the spotlight on replication fork protection in cancer
Nature Cell Biology ( IF 21.3 ) Pub Date : 2017-10-31 , DOI: 10.1038/ncb3638
Katharina Schlacher

PARPi focus the spotlight on replication fork protection in cancer

Nature Cell Biology, Published online: 31 October 2017; doi:10.1038/ncb3638

PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.



中文翻译:

PARPi聚焦于癌症中的复制叉保护

PARPi聚焦于癌症中的复制叉保护

《自然细胞生物学》,在线发布:2017年10月31日; doi:10.1038 / ncb3638

PARP抑制剂(PARPi)可杀死BRCA1 / 2突变的癌症,当恢复DNA修复功能时,这些癌症将具有抵抗力。现在,发现由于EZH2下调而引起的MUS81核酸酶抑制作用可恢复DNA复制叉保护,但不能修复,从而导致突变型BRCA2细胞和患者的PARPi抗性。这对合成杀伤力中的DNA修复优势提出了挑战。

更新日期:2017-10-31
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