In this review, supramolecular catalysis refers to the integration of the catalytic process with molecular self-assembly driven by noncovalent interactions, and dynamic assemblies are the assemblies that form and dissipate reversibly. Cells extensively employ supramolecular catalysis and dynamic assemblies for controlling their complex functions. The dynamic generation of supramolecular assemblies of small molecules has made considerable progress in the last decade, though the disassembly processes remain underexplored. Here, we discuss the regulation of dynamic assemblies via self-assembly and disassembly processes for therapeutics and diagnostics. We first briefly introduce the self-assembly and disassembly processes in the context of cells, which provide the rationale for designing approaches to control the assemblies. Then, we describe recent advances in designing and regulating the self-assembly and disassembly of small molecules, especially for molecular imaging and anticancer therapeutics. Finally, we provide a perspective on future directions of the research on supramolecular catalysis and dynamic assemblies for medicine.

中文翻译：

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药物的超分子催化和动态组装

在本文中，超分子催化是指催化过程与非共价相互作用驱动的分子自组装的整合，而动态组装是可逆地形成和消散的组装。细胞广泛采用超分子催化和动态组装来控制其复杂功能。在过去的十年中，小分子的超分子组装的动态产生取得了长足的进步，尽管拆卸过程仍未得到充分研究。在这里，我们讨论通过用于治疗和诊断的自组装和拆卸过程。我们首先简要介绍单元环境中的自组装和拆卸过程，这些过程为设计控制组装的方法提供了原理。然后，我们描述了设计和调节小分子自组装和拆卸的最新进展，特别是对于分子成像和抗癌治疗。最后，我们对药物的超分子催化和动态组装研究的未来方向进行了展望。