Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

Nature Structural & Molecular Biology, Published online: 23 October 2017; doi:10.1038/nsmb.3489

CD28 signaling motifs are sequestered within the membrane via interactions with phospholipids. TCR activation increases the local Ca²⁺ concentration, which disrupts CD28-lipid interactions.

中文翻译：

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带电脂质和离子动态调节CD28构象和信号转导

带电脂质和离子动态调节CD28构象和信号转导

《自然结构与分子生物学》，在线发布：2017年10月23日；doi：10.1038 / nsmb.3489

通过与磷脂的相互作用，CD28信号转导基序被隔离在膜内。TCR激活会增加局部Ca ²⁺浓度，从而破坏CD28-脂质相互作用。