Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.132

Targeting thermogenesis in brown fat and skeletal muscle to expend energy and reduce fat mass is a promising therapeutic strategy for treating obesity and related metabolic diseases. Here, Betz and Enerbäck discuss the different molecular pathways regulating thermogenesis in these organs and discuss how they can be therapeutically exploited.

中文翻译：

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针对棕色脂肪和肌肉的生热作用，治疗肥胖症和代谢性疾病

针对棕色脂肪和肌肉的生热作用，治疗肥胖症和代谢性疾病

Nature Reviews Endocrinology，在线发表：2017年10月23日；doi：10.1038 / nrendo.2017.132

靶向棕色脂肪和骨骼肌的生热以消耗能量并减少脂肪量是治疗肥胖症和相关代谢疾病的一种有前途的治疗策略。在这里，Betz和Enerbäck讨论了调节这些器官中热生成的不同分子途径，并讨论了如何治疗性地利用它们。