Oxaliplatin (OXA) is a valuable and largely used cancer drug which induces a serious and intractable neuropathy. The lipoyl-homotaurine derivative (ADM_12) reverts in vivo OXA-induced neuropathy, and it is an effective antagonist of the nociceptive sensor channel TRPA1. Unprecedentedly, this safe analgesic showed a synergy with OXA in vitro and proved to inhibit CA IX, a relevant therapeutic target, clearly interfering with pancreatic cancer cells’ aggressiveness.

中文翻译：

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脂酰高牛磺酸衍生物（ADM_12）通过抑制碳酸酐酶IX（CAIX）还原奥沙利铂诱导的神经病并降低癌细胞恶性程度。

奥沙利铂（OXA）是一种有价值且广泛使用的抗癌药物，可引起严重且难治的神经病变。脂酰-高尿嘧啶衍生物（ADM_12）可以逆转体内OXA引起的神经病，它是伤害性传感器通道TRPA1的有效拮抗剂。前所未有的是，这种安全的镇痛药在体外显示出与OXA的协同作用，并被证明可以抑制CA IX（一种相关的治疗靶标），从而明显干扰胰腺癌细胞的侵袭性。