N-substituted thiosemicarbazone–proline hybrids and their iron(III) complexes were synthesized and characterized. The antiproliferative activity of all hybrids and iron(III) complexes was investigated in five human cancer cell lines and one murine cancer cell line. Introduction of aromatic groups and coordination to iron(III) increase the cytotoxic potential of the proligands.

中文翻译：

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末端取代和铁配位对l-脯氨酸-水杨醛-硫代氨基脲杂种抗增殖活性的影响

Ñ取代缩氨基硫脲-脯氨酸杂种及其铁（III）络合物的合成和表征。研究了所有杂种和铁（III）配合物在五种人类癌细胞系和一种鼠类癌细胞系中的抗增殖活性。引入芳族基团和对铁（III）的配位增加了配体的细胞毒性潜能。