The pharmaceutical industry has long known that ∼80% of the results of academic laboratories cannot be reproduced when repeated in industry laboratories. Yet academic investigators are typically unaware of this problem, which severely impedes the drug development process. This academic–industrial complication is not one of deception, but rather a complex issue related to how scientific research is carried out and translated in strikingly different enterprises. This Opinion describes the reasons for inconsistencies between academic and industrial laboratories and what can be done to repair this failure of translation.

中文翻译：

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学术-工业的复杂性：启动失败

制药行业早就知道，当在工业实验室中重复进行时，约80％的学术实验室结果无法复制。然而，学术研究人员通常不知道这个问题，这严重阻碍了药物开发过程。这种学术和工业上的复杂性不是一种欺骗，而是一个复杂的问题，与如何在截然不同的企业中进行科学研究和翻译有关。该意见描述了学术实验室和工业实验室之间不一致的原因，以及可以解决这种翻译失败的问题。