当前位置: X-MOL 学术Cell Metab. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Cell Metabolism ( IF 29.0 ) Pub Date : 2017-10-26 00:00:00 , DOI: 10.1016/j.cmet.2017.09.021
Mark A. Rossi,Garret D. Stuber

Central regulation of food intake is a key mechanism contributing to energy homeostasis. Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain’s reward circuitry both anatomically and functionally. Manipulation of numerous neural pathways can simultaneously influence food intake and reward. Two key systems underlying these processes—those controlling homeostatic and hedonic feeding—are often treated as independent. Homeostatic feeding is necessary for basic metabolic processes and survival, while hedonic feeding is driven by sensory perception or pleasure. Despite this distinction, their functional and anatomical overlap implies considerable interaction that is often overlooked. Here, we argue that the neurocircuits controlling homeostatic feeding and hedonic feeding are not completely dissociable given the current data and urge researchers to assess behaviors extending beyond food intake in investigations of the neural control of feeding.

中文翻译:

重叠的脑回路,用于稳态和享乐性喂养

集中调节食物摄入量是促进能量动态平衡的关键机制。人们认为许多能够协调进食行为的神经回路在解剖学上和功能上都与大脑的奖励回路重叠。操纵许多神经通路可以同时影响食物的摄入和奖励。这些过程的两个关键系统(控制稳态和享乐的系统)通常被视为独立的系统。稳态喂养对于基本的代谢过程和生存是必要的,而享乐喂养则是由感觉或愉悦感驱动的。尽管存在这种区别,但它们的功能和解剖结构重叠意味着经常会忽略很多交互作用。这里,
更新日期:2017-10-27
down
wechat
bug