The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how metabolism can influence chromatin biology and epigenetics, discuss the functional roles of this interplay in developmental and cancer biology, and present future directions in this rapidly emerging area.

中文翻译：

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细胞代谢对染色质动力学和表观遗传学的影响。

营养修饰物和代谢途径的活性会影响用于修饰核酸和染色质的底物。因此，细胞代谢构成染色质状态的基本组成部分，从而构成基因组调控的基本组成部分。在这里，我们描述了新陈代谢如何影响染色质生物学和表观遗传学的生化和遗传原理，讨论了这种相互作用在发育和癌症生物学中的功能作用，并提出了在这一迅速兴起的领域中的未来方向。