当前位置: X-MOL 学术Mol. Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation
Molecular Cell ( IF 16.0 ) Pub Date : 2017-10-19 , DOI: 10.1016/j.molcel.2017.09.001
Matous Hrdinka , Mads Gyrd-Hansen

The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.



中文翻译:

与Met1相关的泛素机制:(去)调控的新兴主题

线性泛素链装配复合物LUBAC是唯一已知的制造蛋氨酸1(Met1)连接的聚泛素(也称为线性泛素)的哺乳动物泛素连接酶。在发现LUBAC是一种功能未知的细胞活动后十年,现在有许多证据将Met1连接的多聚泛素与NF-κB信号传导,细胞死亡,炎症,免疫力和癌症联系起来。我们现在知道,Met1连接的多聚泛素具有有效的信号传导功能,其失调与疾病有关。确实,与Met1连接的多泛素的结合和去结合相关的几个因子的突变和缺陷已被证明与免疫相关疾病有关。在这里,我们讨论了与Met1连接的多聚泛素的作用和调控有关的最新知识和最新见解,

更新日期:2017-10-19
down
wechat
bug