Coactivating and inhibitory receptors that share at least one ligand interact with a wide variety of ligands, indicating their importance in a range of situations. Here, we discuss principles of mainly human paired receptor function and ligand recognition, and possible therapeutic implications of targeting these receptors in cancer, autoimmune diseases, and allergy. We summarise and emphasise the idea that these receptors, which have evolved in part in response to pathogen pressure, fine-tune the immune response, preserve homeostasis, and that pathogens and tumours use the dominance of the inhibitory receptors over the coactivating receptors to avoid immune elimination. Finally, we discuss the options of using paired receptors and their ligand for immune cell education and therapy.

中文翻译：

---

抑制和共激活受体识别相同的配体：病原体和肿瘤利用的免疫稳态。

共有至少一个配体的共激活受体和抑制受体与多种配体相互作用，表明它们在多种情况下的重要性。在这里，我们讨论主要是人类配对受体功能和配体识别的原理，以及在癌症，自身免疫性疾病和过敏症中靶向这些受体的可能的治疗意义。我们总结并强调以下想法：这些受体在一定程度上响应病原体压力而进化，可以调节免疫反应，保持体内平衡，并且病原体和肿瘤利用抑制性受体在共激活受体上的优势来避免免疫。消除。最后，我们讨论了使用配对受体及其配体进行免疫细胞教育和治疗的选择。