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Detection of vapor-phase organophosphate threats using wearable conformable integrated epidermal and textile wireless biosensor systems
Biosensors and Bioelectronics ( IF 12.6 ) Pub Date : 2017-10-20 , DOI: 10.1016/j.bios.2017.10.044
Rupesh K. Mishra , Aida Martín , Tatsuo Nakagawa , Abbas Barfidokht , Xialong Lu , Juliane R. Sempionatto , Kay Mengjia Lyu , Aleksandar Karajic , Mustafa M. Musameh , Ilias L. Kyratzis , Joseph Wang

Flexible epidermal tattoo and textile-based electrochemical biosensors have been developed for vapor-phase detection of organophosphorus (OP) nerve agents. These new wearable sensors, based on stretchable organophosphorus hydrolase (OPH) enzyme electrodes, are coupled with a fully integrated conformal flexible electronic interface that offers rapid and selective square-wave voltammetric detection of OP vapor threats and wireless data transmission to a mobile device. The epidermal tattoo and textile sensors display a good reproducibility (with RSD of 2.5% and 4.2%, respectively), along with good discrimination against potential interferences and linearity over the 90–300 mg/L range, with a sensitivity of 10.7 µA∙cm3∙mg−1 (R2 = 0.983) and detection limit of 12 mg/L in terms of OP air density. Stress-enduring inks, used for printing the electrode transducers, ensure resilience against mechanical deformations associated with textile and skin-based on-body sensing operations. Theoretical simulations are used to estimate the OP air density over the sensor surface. These fully integrated wearable wireless tattoo and textile-based nerve-agent vapor biosensor systems offer considerable promise for rapid warning regarding personal exposure to OP nerve-agent vapors in variety of decentralized security applications.



中文翻译:

使用可穿戴的整合表皮和纺织品无线生物传感器系统检测气相有机磷的威胁

柔性表皮纹身和基于纺织品的电化学生物传感器已被开发用于有机磷(OP)神经毒剂的气相检测。这些新的可穿戴式传感器基于可拉伸的有机磷水解酶(OPH)酶电极,与完全集成的共形柔性电子接口相结合,可提供对OP蒸气威胁的快速和选择性方波伏安检测以及向移动设备的无线数据传输。表皮纹身和纺织品传感器显示出良好的可重复性(相对标准偏差分别为2.5%和4.2%),并对90-300 mg / L范围内的潜在干扰和线性有很好的辨别力,灵敏度为10.7 µA∙cm 3 ∙毫克-1(R 2= 0.983)和OP空气密度的检测极限为12 mg / L。用于印刷电极换能器的耐应力油墨可确保抵御与纺织品和基于皮肤的人体感应操作相关的机械变形。理论模拟用于估计传感器表面上的OP空气密度。这些完全集成的可穿戴无线纹身和基于纺织品的神经毒剂蒸气生物传感器系统为在各种分散式安全应用中个人暴露于OP神经毒剂蒸气的快速警告提供了可观的前景。

更新日期:2017-10-20
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