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Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment
Cell Metabolism ( IF 29.0 ) Pub Date : 2017-10-19 00:00:00 , DOI: 10.1016/j.cmet.2017.09.015
Pernille Hojman,Julie Gehl,Jesper F. Christensen,Bente K. Pedersen

The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies.

中文翻译:

运动与癌症预防和治疗相关的分子机制

运动训练对癌症患者的好处越来越明显。体育锻炼已被证明可以减少癌症的发生并抑制肿瘤的生长。在这里,我们提供了运动对癌症影响的当前分子理解的状态。我们建议运动通过直接影响肿瘤内在因素,与全身运动效果相互作用,减轻与癌症有关的不良事件以及提高抗癌治疗功效来控制癌症的进展。这些发现具有广泛的社会意义,因为这种理解可能会导致癌症治疗策略的改变。
更新日期:2017-10-19
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