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More than One Way to Skin a Catalyst
Cell Chemical Biology ( IF 8.6 ) Pub Date : 2017-10-19 , DOI: 10.1016/j.chembiol.2017.10.004
Stephen W. Michnick

In this issue ofCell Chemical Biology,Diaz et al. (2017)report a strategy to achieve temporal, spatial, and stoichiometric control over the protein kinase cAbl in living cells. They achieve this by splitting cAbl into two inactive fragments that form an active kinase upon small molecule addition, potentially providing a general way to probe the wiring of signal transduction networks.

中文翻译:

涂催化剂的多种方法

在本期《细胞化学生物学》中,Diaz等人。(2017)报告了在活细胞中实现对蛋白激酶cAbl进行时间,空间和化学计量控制的策略。他们通过将cAbl分裂成两个无活性的片段来实现这一目标,这些片段在添加小分子时形成了一个活性激酶,可能提供一种探测信号转导网络布线的一般方法。
更新日期:2017-12-14
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