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How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD
Journal of the American College of Cardiology ( IF 24.0 ) Pub Date : 2017-10-01 , DOI: 10.1016/j.jacc.2017.09.001
Kimberly N. Hong , Valentin Fuster , Robert S. Rosenson , Clive Rosendorff , Deepak L. Bhatt

Diabetes, hyperlipidemia, and hypertension are modifiable risk factors that predict cardiovascular disease events. The effect of these risk factors on incident cardiovascular disease increases with progressively higher levels of glucose, low-density lipoprotein cholesterol, and blood pressure. The thresholds for initiating treatment of these modifiable risk factors and the optimal goals of risk factor modification are a focus of primary prevention research. Although an aggressive approach is appealing, adverse events may occur, and potential physiological barriers may exist. This paper discusses primary prevention of coronary heart disease that may be achieved through modification of diabetes, hyperlipidemia, and hypertension by summarizing current guidelines and pertinent clinical trial data from intervention trials that included a primary prevention cohort.

中文翻译:

在心血管疾病的一级预防中,血糖、胆固醇和血压有多低

糖尿病、高脂血症和高血压是可改变的预测心血管疾病事件的危险因素。这些风险因素对心血管疾病的影响随着葡萄糖、低密度脂蛋白胆固醇和血压水平的逐渐升高而增加。开始治疗这些可改变的危险因素的阈值和危险因素修改的最佳目标是一级预防研究的重点。尽管积极的方法很有吸引力,但可能会发生不良事件,并且可能存在潜在的生理障碍。本文讨论了通过改变糖尿病、高脂血症、
更新日期:2017-10-01
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